Several maternal disorders have been identified in which the
risk of fetal malformations is increased, including diabetes and
phenylketonuria. The risk of congenital malformations in the
pregnancies of diabetic women is two to three times higher
than that in the general population but may be lowered by
good diabetic control before conception and during the early
part of pregnancy. In phenylketonuria the children of an
affected woman will be healthy heterozygotes in relation to the
abnormal gene, but if the mother is not returned to a carefully
controlled diet before pregnancy the high maternal serum
concentration of phenylalanine causes microcephaly in the
developing fetus.
Subscribe to:
Post Comments (Atom)
No comments:
Post a Comment